Research Interests

Modulation of neuronal network oscillations and their co-relations with neurodegenerative diseases
Generation, expression and pharmacological modulation of SPW-Rs, gamma oscillations
Synaptic plasticity and Cellular mechanism of memory consolidation
Neurotransmission
Cellular mechanisms underlying epilepsies
Pharmacology of natural products
Methods :
Field potential recordings with multiple electrodes
Intracellular recordings with sharp microelectrodes
Ion sensitive microelectrode
Rodents hippocampal slices
Spontaneously occurring and pharmacologically or stimulus induced neuronal oscillations
Models of temporal lobe epilepsy
Animal models of different neuropharmacological activities

Post Doctorate:

Title of research; Induction of Long‐term Potentiation in Area CA1 by
sharp wave‐ripple Complexes in vitro. Supervisor Prof. Dr. Uwe Heinemann, Institute
of Neurophysiology, Charite Universitätsmedizin Berlin, Germany; October 2011 to
October 2012.
PhD:

Title of thesis; Modulation of hippocampal sharp wave‐ripple activity in vitro.
Supervisor Prof. Dr. Uwe Heinemann, Institute of Neurophysiology, Charite
Universitätsmedizin Berlin, Germany; May 2007 to October 2011. Defense date
October 31, 2011. Degree awarded with Summa cum laude.
M. Phil in Pharmacology:

Title of thesis; Antitussive evaluation of some medicinal
plants of Pakistan. Supervisor Prof. Dr. Rafeeq Alam Khan, Department of
Pharmacology, Faculty of Pharmacy, University of Karachi, 2005.
B. Pharmacy:

Faculty of Pharmacy, Gomal University, D. I. Khan, 1996‐2000.

1. Rehman MU, Ali N, Jamal M, Kousar R, Ishaq M, Awan AA, Hussain I, Sherkheli MA, Ul Haq R*. Comparison of acute and chronic effects of Bacopa monnieri, Ginkgo biloba, and Lavandula angustifolia and their mixture on learning and memory in mice. Phytother Res. 2021 Jan 11. doi: 10.1002/ptr.7016 Impact fact 5.87

2. Mushtaq M, Haq RU, Anwar W, Marshall L, Bazhenov M, Zia K, Alam H, Hertel L, Awan AA, Martinetz T. A computational study of suppression of sharp wave ripple complexes by controlling calcium and gap junctions in pyramidal cells..Bioengineered. 2021 Dec;12(1):2603-2615. doi: 10.1080/21655979.2021.1936894. Impact factor 3.26

3. Berndt N, Rosner J, Haq RU, Kann O, Kovacs R, Holzhatter HG, Spies C, Liotta A. Possible neurotoxicity of the anesthetic propofol: evidence for the inhibition of complex II of the respiratory chain in area CA3 of rat hippocampal slices. Archives of Toxicology. 2018 Oct;92(10):3191-3205. doi: 10.1007/s00204-018-2295-8. Epub 2018 Aug 24. Impact factor: 5.9
4. Jamal M,  Rehman MU, Nabi M, Awan AA, Niaz Ali, Sherkheli MA, ul Haq R*. Evaluation of safety profile and stress suppressant activity of Rosa moschata in mice. Pakistan Journal of Pharmaceutical Sciences. Accepted. Impact factor: 0.82
5. Angamo EA, Ul Haq R, Rosner J, Gabriel S, Gerevich Z, Heinemann U, Kovacs R. Contribution of Intrinsic Lactate to Maintenance of Seizure Activity in Neocortical Slices from Patients with Temporal Lobe Epilepsy and in Rat Entorhinal Cortex. International Journal of Molecular Sciences. 2017: 18(9): pii 1835. Impact factor: 3.2
6. Ul Haq R*, Anderson M, Liotta A, Shafiq M, Sherkheli MA, Heinemann U. Pretreatment with beta-2-adrenergic receptor agonists facilitates induction of LTP and sharp wave ripple complexes in rodent hippocampus. Hippocampus. 2016: 26(12): 1486-1492. Impact factor: 4.2
7. ul Haq R, Anderson MA, Hollnagel J-O , Sherkheli MA, Behrens CJ, Heinemann U. Serotonin dependent masking of hippocampal sharp wave ripples. Neuropharmacology. 2016: 101; 188.203. Impact factor: 5.1
8. Jarosch MS, Gebhardt C, Huchzermeyer C, ul Haq R, Behrens CJ , Heinemann U. Early adenosine release contributes to hypoxia induced disruption of stimulus induced sharp wave ripple complexes in rat hippocampal area CA3. European Journal of Neuroscience 2015: 42(2): 1808-17. Impact factor: 3.2
9. Hollnagel J-O, ul Haq R, Behrens CJ, Maslarova A, Mody I, Heinemann U. No evidence for role of extracellular choline-acetyltransferase in generation of gamma oscillations in rat hippocampal slices in vitro. Neuroscience. 2015: 284: 459-69. Impact factor: 3.2
10. Sherkheli MA, Schreiner B, Hameed A, ul Haq R, Werner M, Hatt H. Borneol inhibits TRPA1, a proinflammatory and noxious pain-sensing cation Channel. Pakistan Journal of Pharmaceutical sciences 2015: 28(4): 1357-1364. Impact factor: 0.82
11. Hollnagel J-O, Maslarovo A, ul Haq R, Heinemann U. GABAB receptor dependent modulation of sharp wave-ripple complexes in the rat hippocampus in vitro. Neuroscience Letters 2014: 574; 15-20. Impact factor: 2.2
12. Riffat F, Khan RA, Khalid M, Haq RU. Evaluation of antitussive efficacy of herbal syrup. Medical Channel. 2014: 20(3): 34-37.
13. ul Haq R, Wahab A, Ayub A, Mehmood K, Sherkheli MA, Khan RA, Raza M. Antitussive Efficacy and Safety Profile of Ethyl Acetate Fraction of Terminalia chebula. ISRN Pharmacology. 2013: http://dx.doi.org/10.1155/2013/256934.
14. Hameed H, Sherkheli MA, Hussain A, Ul Haq R. 2013. Molecular and physiological determinants of pulmonary developmental biology: a review. American Journal of Biomedical Research. 2013: 1(1): 13-24.
15. Ul Haq R, Liotta A, Kovacs R, Roesler A, Jarosch MJ, Heinemann U, Behrens CJ. Adrenergic modulation of sharp wave-ripple activity in rat hippocampal slices. Hippocampus 2012 Mar;22(3):516-33. Impact factor: 4.9
16. Haq RU, Shah IU, Ullah Z, Khan RA, Malik A. 2012. Antitussive and toxicological evaluation of Vitex negundo. Natural Product Research 26(5):484-8. Impact factor: 1.8
17. Behrens CJ, ul Haq R, Liotta A, Heinemann U. 2011. Nonspecific effects of the gap junction blocker mefloquine on fast hippocampal network oscillations in the adult rat in vitro. Neuroscience 9;192:11-9. Impact factor: 3.2
18. Liotta A, Caliskan G, Ul Haq R, Hollnagel JO, Roesler A, Heinemann U, Behrens CJ. Partial disinhibition is required for transition of stimulus-induced sharp wave-ripple complexes to recurrent epileptiform discharges in rat hippocampal slices. J Neurophysiol. 105(1):172-187, 2011. Impact factor: 3.2
19. Haq RU*, Farooq U, Wahab A, Raza M, Ahmad VU, Khan RA. 2011. Investigation of antitussive and toxicological activity of Ballota limbata in mice. Pharmaceutical Biology 49(6):627-632. Impact factor: 2.2
20. Decker JM, Wojtowicz AM, ul Haq R, Braunewell KH, Heinemann U, Behrens CJ. 2009. C-type natriuretic peptide decreases hippocampal network oscillations in adult rats in vitro. Neuroscience 164:1764-1775. Impact factor: 3.2
21. Ul Haq R, Liotta A, Jarosch MS, Heinemann U, Behrens CJ. 2009. Neuromodulatory effects of norepinephrine on stimulus-induced sharp wave-ripple complexes in the adult rat hippocampus in vitro. European Journal of Medical Research. 14(2) Sup 168. (Conference abstract published in impact factor Journal). Impact factor: 2.1
22. Wojtowicz AM, van den Boom L, Chakrabarty A, Maggio N, Haq R U, Behrens C J, Heinemann U. 2009. Monoamines block kainate- and carbachol-induced gamma oscillations but augment stimulus-induced gamma oscillations in rat hippocampus in vitro. Hippocampus 19(3):273-288. Impact factor: 5.2
23. Wojtowicz A, Chakrabarty A, Maggio N, ul Haq R, Behrens CJ, Heinemann U. 2009. Monoamines effets on different types of hippocampal gamma oscillations in adult rat in vitro. Acta Neurobiologiae Experimentalis 3 (69). (Conference abstract published in impact factor Journal). Impact factor: 1.2
24. Wahab A, Haq RU, Ahmed A, Khan RA, Raza M. 2009. Anticonvulsant activities of nutmeg oil of Myristica fragrans. Phytotherapy Research 23(2):153-158. Impact factor: 3.2
25. Wahab A, Ahmed E, Nawaz SA, Sharif A, Haq RU, Malik A, Choudhary MI, Raza M. 2008. A pharmacological and toxicological evaluation of Haloxylon recurvum. Natural Product Research 22(15):1317-1326. Impact factor: 1.8
26. Khan RA, Sadruddin S, Haq RU, Mirza T. Antitussive effect of herbal tea on chemical induced coughing in mice. Journal Basic Applied Sciences. 2006: 2 (2): 79-82.