Phylogenetic study of 46 Ancient Mitochondrial Human Genomes

Phylogenetic study of 46 Ancient Mitochondrial Human Genomes

Abstract

Background: In the third era of ancient DNA field, it has endured the mesmerising modifications,
which should be revealed. From side to side period, analysis of mitochondrial DNA permits to
determine the evolutionary relationship among the species, to expose the terrestrial roots of the
entities, to standardise the molecular clocks and to study the demographic pasts.
Methods: In the current study we used bioinformatics tools for prediction of mitochondrial haplogroups
and phylogenetic analysis. The ancient complete mitochondrial genomes were retrieved from online
resources and were further used for phylogenetic analysis to know the evolutionary position of the ancient
populations lived thousands of years ago.
Results: We aligned 46 ancient genomes, collected online and estimated trees by using neighbour-joining,
maximum parsimony and maximum-likelihood. Support for nodes was assessed with bootstrap replicates.
During our analysis a strong bond between genomes of Altai Neanderthal, Motala 12, Motala 1,
Loschbour, Ust'-Ishim, LBK, Mezmaiskaya Neanderthal, Denisova, RISE391(ERR844272), Clovis Anzick-
1, RISE395(ERR844275) and RISE210(ERR844262) were found. In this context these ancient samples
recommended the presence of a mutual earliest genomic signature.
Conclusion: A significant population immigrations and alternates, accountable for influencing main
parts of current demographic structure together in Europe and Asia is supported by the Bot15
(ERR668415) and RISE family. In the initial bronze period, ancestral similarity among these populations
also share the theorised blow-out of Indo-European languages. Mechanisms of pathogen development
and alteration for evolving and reappearing toxicities is also explained by this study. We aim that this
study will help researchers in understanding the evolutionary position of ancient populations resided
around the world.
 

No. of Pages
71-75
Volume
6(2)
Author's Details
Aqsa Khan, Nasir Ali, Wajiha Shafique, Ghani ur Rahman, Shaker Khan, Gohar Rahman, Bilal Ahmad Mian, Nazia Akbar, Habib Ahmad
Research Field
Bioinformatics